According to a regional news website, the accident took place in Sunnampukuttai, a village near Pernambut. The car in which she was travelling hit the median at a high speed and toppled, killing the actress and three others, on the spot.
The other deceased have been identified as Abhishek Kumaran (22), Jayachandran (23) and Rakshan (20).
The actress along with the injured co-passengers was rushed to Thirupatthur government hospital where she was declared brought dead.
Rekha Sindhu was known for her work in Tamil and Kannada TV shows.