He was 55.
Patil was recently admitted to a private hospital in Mumbai for liver transplant where he died at around 12.30 am today, his family said.
The leader was a Member of Parliament twice from Sangli Lok Sabha constituency.
He had earlier also been an MLA from Sangli Assembly seat and had served as a minister in the earlier Congress-led state government.
He was the grandson of Maharashtra’s former Chief Minister late Vasantdada Patil.